Insulin-mediated vasodilation and forearm plethysmography: physiology not pharmacology
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چکیده
منابع مشابه
Insulin--history, biochemistry, physiology and pharmacology.
The discovery of insulin was a seminal event in both the study of diabetes and the care of diabetic pa tients. The development of procedures for purifying and modifying insulin took an additional 30 years. In his masterful rendition of these developments, Mi chael Bliss recounts the remarkable story surrounding the discovery of insulin and notes that the discovery of insulin at the University o...
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Meal-induced sensitization to the dynamic actions of insulin results from the peripheral actions of a hormone released by the liver (hepatic insulin sensitizing substance or HISS). Absence of meal-induced insulin sensitization results in the pathologies associated with cardiometabolic risk. Using three protocols that have previously demonstrated HISS metabolic action, we tested the hypothesis t...
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Forearm venous occlusion plethysmography is widely used for the study of arterial function in vivo in humans. In their timely paper on the effect of the angiotensinconverting enzyme inhibitor lisinopril on endothelial function in hyperlipidaemic patients, Lee et al. [1] raised several points of methodology relating to the correct analysis and presentation of data. Blood flow was measured in bot...
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The effect of hypercholesterolemia on vascular function was studied in humans. To eliminate the potential confounding effects of atherosclerosis, vascular reactivity was measured in the forearm resistance vessels of 11 normal subjects (serum LDL cholesterol = 111±7 mg/dl) and 13 patients with hypercholesterolemia (serum LDL cholesterol = 211±19 mg/dl, P < 0.05). Each subject received intrabrach...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1999
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051453